Study partners should be required in preclinical Alzheimer’s disease trials

Cognitive Impairments in Siblings of Alzheimers Disease Patients: Possible Preclinical Signs of the Disease

How should zoster trials be conducted?

In 1994, an international group of interested clinicians and biostatisticians met to discuss the design of clinical trials in herpes zoster. They agreed that trials in herpes zoster should have prospectively agreed definitions of all outcome measures and plans for data analysis. In immunocompetent individuals, in whom pain is the major outcome measure, trials should only include patients over t...

I-14: Assisted Reproduction and Religion What Consideration Should Be and Should Not Be Relevant,

Several important issues are pertinent to an ethical discussion of the new technology today grouped under the name Assisted Reproduction Technology (ART). This is a moral imperative because each of us must decide what is to be considered ethically acceptable in assisted reproduction. Reflecting on the ethical dimension of ‘creating’ a new human life can play a major role in ensuring that in eac...

Should randomized clinical trials be required for proton radiotherapy? An alternative view.

Recently, several articles have been published in the Journal of Clinical Oncology and other journals reviewing and commenting on the record of proton beam therapy, as well as an analysis including some critical commentary by Brada et al. All of these articles make the uncontested point that there are almost no randomized clinical trials (RCTs) comparing proton beam therapy with conventional x-...

Staphylococcus lugdunensis; a pathogen that should be considered in Iran

Background: Staphylococcus lugdunensis is Gram-positive cocci of the staphylococcaceae family. S. lugdunensis despite having a clotting factor (wall coagulase), was classified in the coagulase negative staphylococcus group (CoNS) for lack of free coagulase. Although this bacterium is part of the human normal flora, in terms of virulence, S. lugdunensis is in second place after S. aureus. S. lug...